- Laura Prepon returns as a series regular.
- Pornstache's mother will be making an appearance.
- This season will be focused on faith. 
- Jason Biggs did not return for Season Three, while Pablo Schreiber (who had previously been reported to also not be returning) appeared in a single episode.
- Mary Steenburgen, Marsha Blake, Blair Brown, Ruby Rose, and Mike Birbiglia will be joining the cast.
- Nick Sandow, Selenis Leyva, Samira Wiley, Adrienne C. Moore, Dascha Polanco and Yael Stone have all been promoted to series regulars.
Each episode has a focal character, and often more than one. These characters have flashbacks and are a big part of the episode.