- Jenji Kohan: episodes 1 and 13
- Jim Danger Gray: episodes 2 and 13
- Nick Jones: episodes 3 and 8
- Lauren Morelli: episodes 4 and 10
- Tara Herrmann: episode 5
- Sara Hess: episodes 6 and 12
- Sian Heder: episodes 7 and 11
- Jordan Harrison: episode 9
- Andrew McCarthy: episodes 1 and 9
- Constantine Makris: episodes 2 and 4
- Michael Trim: episode 3
- Nicole Holofcener: episode 5
- Anthony Hemingway: episode 6
- Julie Anne Robinson: episode 7
- Mark A. Burley: episode 8
- Jesse Peretz: episode 10
- Phil Abraham: episodes 11 and 13
- Uta Briesewitz: episode 12
- Laura Prepon returns as a series regular.
- Pornstache's mother will be making an appearance.
- This season will be focused on faith. 
- Jason Biggs did not return for Season Three, while Pablo Schreiber (who had previously been reported to also not be returning) appeared in a single episode.
- Mary Steenburgen, Marsha Blake, Blair Brown, Ruby Rose, and Mike Birbiglia will be joining the cast.
- Nick Sandow, Selenis Leyva, Samira Wiley, Adrienne C. Moore, Dascha Polanco and Yael Stone have all been promoted to series regulars.
Each episode has a focal character, and often more than one. These characters have flashbacks and are a big part of the episode.